Distinct roles for DH and PH domains in the Lbc oncogene
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چکیده
منابع مشابه
The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex
The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We have determined the X-ray crystal structure of the complex between RhoA-GDP and the AKAP-Lbc Rho...
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Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia
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ژورنال
عنوان ژورنال: Oncogene
سال: 1997
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1201594